摘要 |
Compounds of formula (1), or a pharmaceutically acceptable salt thereof, wherein: R<0> is OH or a bioprecursor thereof, R<1> is A<0>CO2H, P(Z)(OH)(OR<2>), SO2H, SO3H or 5-tetrazolyl or a bioprecursor thereof, A<0> is CH2, CHF, CF2, CR<3>(OR<4>), CO or C(OR<5>)(OR<6>), are described as agonists of a cyclic AMP dependent protein kinase. They are useful as medicaments. |