COMPLEXES COMPRISING ANGIOSTATIN AND ITS FRAGMENTS, PREPARATION PREPARING METHODS AND USES THEREOF

摘要

A medicament useful for treating tumors or angiogenesis mediated diseases, medical compositions and kits comprising the medicament and a method for preparing the medicament are provided. The medicament contains complexes of a modifier and angiostatin or its fragments, which have longer in vivo half-life than non-modified angiostatin or its fragments. The modifier is selected from high molecular polymers, proteins or their fragments, polypeptides, small molecules and any other type of compounds.