BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES THEIR CONJUGATES, PROCESSES FOR THEIR PREPARATION, AND USE AS RADIOPHARMACEUTICALS

摘要

2103553 9312112 PCTABS00022 Complexes of bicyclopolyazamacrocyclocarboxylic acid compounds with a metal ion, e.g. 153Sm, 177Lu, 159Gd, 149Pm, 140La, 175Yb, 166Ho, 90Y, 47Sc, 186Re, 188Re, 142Pr, 99mTc, 67Ga, 68Ga, 105Rh, 97Ru, 111In, 113mIn or 115mIn ion, are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as radiopharmaceutical agents for therapy and/or diagnostic purposes. Processes to prepare the complex and conjugate are discussed.