PYRAZOLOTHIAZOLOPYRIMIDINE DERIVATIVES

摘要

The present invention relates to pyrazolothiazolopyrimidine derivatives represented by the following Formula (I): (I) in which R1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, halogen or -NR3R4 (in which R3 and R4 represent independently hydrogen, lower alkyl, lower alkanoyl or aroyl); when R2 is a substituent on the 1-position, X represents N or CH, and R2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or lower alkoxycarbonyl; when R2 is a substituent on the 2-position, X represents N, and R2 represents -CR5R6R7 (in which R5 represents substituted or unsubstituted lower alkyl; and R6 and R7 represent independently hydrogen or lower alkyl), substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or lower alkoxycarbonyl; Y represents O or S; Q represents -CR8R9CR10R11-(CH2)n- or -CR8=R9-(CH2)n- (in which R8, R9, R10 and R11 represent independently hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or lower alkoxycarbonyl; and n is an integer of 0 to 2) and pharmaceutically acceptable salts thereof which are useful as anti-inflammatory, analgesic, immunomodulatory and antiulcer agents.