发明名称 |
Methods for Tissue Engineering |
摘要 |
The invention relates to the use of parathyroid hormone-related protein (PTHrP) in the prevention of hypertrophy in chondrogenic cells for cartilage replacement. A method for engineering three dimensional cartilage constructs from chondrogenic cells is provided, said method comprising a step of treating the chondrogenic cells or immature constructs with PTHrP to regulate hypertrophy. Also provided are: three dimensional cartilage produced by the method of the invention, and an engineered cartilage construct comprising chondrogenic cells and a bioactive scaffold capable of controlled release of PTHrP. In addition, the invention provides a method for the treatment of osteoarthritis.
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申请公布号 |
US2008318859(A1) |
申请公布日期 |
2008.12.25 |
申请号 |
US20060994758 |
申请日期 |
2006.07.06 |
申请人 |
THE UNIVERSITY OF BRISTOL |
发明人 |
HOLLANDER ANTHONY P.;KAFIENAH WA'EL Z. |
分类号 |
A61K38/29;A01N1/02;A61L27/38;C07K14/635;C12N5/077 |
主分类号 |
A61K38/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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