发明名称 |
METHOD OF CONTROLLING CULTURE AND APPARATUS THEREFOR |
摘要 |
A method of controlling culture wherein cells are aerobically cultured to produce metabolite is characterized by adding substrate and/or inducer to the culture broth, judging the endpoint of the growth of the cells and/or the production of the metabolite or terminating the culture under the guidance of a change in the ratio of the first parameter based on the amount of carbon dioxide evolved by the cell culture to the second parameter based on the amount of oxygen consumed by the cell culture. The ratio is a respiratory quotient, for instance. |
申请公布号 |
EP0196061(B1) |
申请公布日期 |
1993.06.09 |
申请号 |
EP19860104079 |
申请日期 |
1986.03.25 |
申请人 |
HITACHI, LTD. |
发明人 |
SHIMIZU, NORIO;FUKUZONO, SHINICHI;NISHIMURA, NOBUKO;ODAWARA, YOJI;SUMITANI, TOMOAKI |
分类号 |
C12M1/36;C12N1/00;C12N1/20;C12N1/21;C12N9/38;C12P21/02;C12R1/19;C12R1/545 |
主分类号 |
C12M1/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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