发明名称 1,4-DIHYDROPYRIDINDERIVATE.
摘要 Compounds are described of the formula <CHEM> wherein R1 and R4 independently represent a C1-4 alkyl group; R2 and R3 independently represent a C1-6 straight or brached alkyl chain or alkoxy group; R4 represents a C1-4 alkyl group; R5 represents a group CH=CR6R7 where R6 is a hydrogen atom or C1-3 alkyl group and R7 represents an aryl, pyridyl or cyano group; or R5 represents the group C IDENTICAL CR8 where R8 is an aryl group. The compounds represented by formula (1) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.
申请公布号 DE3785695(D1) 申请公布日期 1993.06.09
申请号 DE19873785695 申请日期 1987.02.19
申请人 GLAXO S.P.A., VERONA, IT 发明人 SEMERARO, CLAUDIO, BRESSO (MILANO), IT;MICHELI, DINO;PIERACCIOLI, DANIELE;GAVIRAGHI, GIOVANNI, VERONA, IT;BORTHWICK, ALAN DAVID, LONDON, NW11 7UA, GB
分类号 A61K31/445;A61K31/4422;A61K31/451;A61P9/00;A61P9/10;C07D211/90;C07D401/10;(IPC1-7):C07D211/90;A61K31/44 主分类号 A61K31/445
代理机构 代理人
主权项
地址