摘要 |
Compounds containing carbohydrate moieties or carboxyl groups are linked to either compounds containing thiol moieties or electron-deficient moieties by the use of linking agents of the formula <IMAGE> in which R1 is NH2- or NH2-NH-; R2 is -NH-C(O)-, -C(O)-NH-, or -C(O)-; R3 is C1-C10 alkylene, C5-C7 cyclic alkylene, arylene, phenyl-substituted C1-C10 alkylene, benzyl-substituted C1-C10 alkylene, or amino-substituted C1-C10 alkylene; R4 is H, acetyl, <IMAGE> <IMAGE> where R5 is C1-C5 alkyl; m is zero or 1; and n ia zero or 1.
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