发明名称 Linking agents and methods
摘要 Compounds containing carbohydrate moieties or carboxyl groups are linked to either compounds containing thiol moieties or electron-deficient moieties by the use of linking agents of the formula <IMAGE> in which R1 is NH2- or NH2-NH-; R2 is -NH-C(O)-, -C(O)-NH-, or -C(O)-; R3 is C1-C10 alkylene, C5-C7 cyclic alkylene, arylene, phenyl-substituted C1-C10 alkylene, benzyl-substituted C1-C10 alkylene, or amino-substituted C1-C10 alkylene; R4 is H, acetyl, <IMAGE> <IMAGE> where R5 is C1-C5 alkyl; m is zero or 1; and n ia zero or 1.
申请公布号 US5218112(A) 申请公布日期 1993.06.08
申请号 US19900573615 申请日期 1990.08.27
申请人 XOMA CORPORATION 发明人 REARDAN, DAYTON T.;GOFF, DANE A.
分类号 C07C323/20;C07C323/32;C07C327/30;C07D213/71;G01N33/531 主分类号 C07C323/20
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