摘要 |
A method of treating depression comprising administering to a patient an effective antidepressive amount of a compound of the formula <IMAGE> wherein either (i) the endocyclic dotted line ( ) is a double bond; the exoxyclic dotted line ( ) is a single bond; A is <IMAGE> m is 1; n is 0; R3 and R4 are hydrogen, C1-C4 alkyl, benzyl or phenyl or R3, R4 and the nitrogen to which they are attached represent an alicyclic amino having 5 or 6 ring atoms, of which one ring atom is nitrogen and one ring atom is optionally an additional nitrogen, oxygen or sulfur heteroatom; R1 is hydrogen, halogen C1-C4 alkyl C2-C4 alkenyl, C2-C4 alkynyl, benzyl or phenyl; and R2 is hydrogen, C1-C4 alkyl phenyl or a 5- or 6- membered heterocyclic; or (ii) the endocyclic dotted line ( ) is a single bond; the exocyclic dotted line ( ) is a double bond; A is oxygen; B is <IMAGE> m is 0; n is 1; R3, R4 and the nitrogen to which they are attached together represent an alicyclic amino group having 5 or 6 ring atoms, of which one ring atom is nitrogen and one ring atom is optionally an additional nitrogen, oxygen or sulfur heteroatom; and R1 and R2, together with the carbon to which they are attached, represent phenyl fused to the isoxazole ring.
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