| 摘要 |
Non-peptidyl compounds characterized generally as benzothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy beta -amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula <IMAGE> wherein R1 is selected from <IMAGE> wherein each of Y and Z is independently selected from hydrido, chloro, fluoro, methoxy and dimethylamino; wherein X is sulfur atom; wherein n is a number selected from zero through four, inclusive; wherein each of R2 and R4 is independently selected from hydrido and methyl; wherein R3 is methyl or ethyl; wherein R5 is cyclohexylmethyl; wherein R6 and R7 are taken together to form a partially saturated or fully saturated heterocyclic ring containing five to eight ring members with one or two ring members being oxygen atoms and the remaining ring members being carbon atoms, and which heterocyclic ring may be optionally substituted with lower alkyl; or a pharmaceutically-acceptable salt thereof.
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