RECOMBINANT AMYLOID PRECURSOR PROTEIN INHIBITOR DOMAIN AND TREATMENT OF VARIOUS DISEASE STATES

摘要

The present invention relates to the production of a Kuniz type protease inhibitor (KPI) peptide, and its use in regulating protease activity associated with amyloidosis. This invention is further directed to in vivo and in vitro models of amyloidosis involving the KPI peptide. The KPI peptide can also be used to treat coagulation disorders by regulating proteases in the coagulation pathway. KPI is also used to inhibit or ameliorate protease-associated damage following injury, especially head injury. Nucleic acid sequences encoding the protease inhibitor and expression systems for high level expression of the active inhibitor are provided.