E-ISOMERE VON N ALPHA-(2-CYAN-2-ALKOXIMINO-ACETYL)-AMINO-SAEUREDERIVATEN UND -PEPTIDEN.

摘要

E-Isomers of N(alpha)-(2-cyano-2- alkoxyamino acetyl)amino acid derivs. and peptides of formula (I) and their physiologically tolerable ammonium, substd. ammonium, alkali and alkaline earth salts and metal salt complexes are new. R = alkyl, alkenyl, alkynyl, cyanoalkyl, azolylalkyl, opt. substd. phenylalkyl or opt. substd. cycloalkyl; R1 = H, alkyl opt. substd. phenyl, opt. benzyl or alkoxycarbonylamino; R2 = H or alkyl; R3 = H, alkyl, alkoxycarbonylalkyl, hydroxycarbonylalkyl, aminocarbonylalkyl, azolylalkyl, cyanoalkyl, hydroxyalkyl, alkenyl, alkynyl, opt. substd. cycloalkyl, opt. substd. phenyl or phenylalkyl, or the grouping R4-S(O)n-Z-; n = 0, 1 or 2; Z = opt. branched alkylene; R4 = H, alkyl or opt. substd. phenylalkyl; or R1 and R3 together with the N-atom and the C-atom to which they are attached form a 5- or 6-membered heterocycle; or R2 and R3 together with the C-atom to which they are attached form a cycloalkylidene group; X = ORI or NRIIRIII; RI = H, alkyl, alkenyl or alkynyl; RII = H or alkyl; RIII = H, alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, dialkylaminoalkyl, alkoxycarbonylalkyl, hydroxycarbonylalkyl, aminocarbonylalkyl, alkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, cyanoalkyl, opt. substd. phenylalkyl, opt. substd. phenyl, opt. substd. cycloalkyl, acylamino, or the grouping -N=CH-RIV; or NRIIRIII = opt.substd. heterocycle which may contain further heteroatoms; RIV = alkyl or opt. substd. phenyl.