Process for the preparation of sulfonated polyethyleneoxide-substituted polymers with improved blood compatibility

摘要

Novel sulfonated polyethyleneoxide-substituted polymers having improved blood compatibility are provided. The polymers are produced by substituting a polymeric substrate having active sites of amide or acid amide group, such as polyurethane, polyamide and polyacrylamide, with sulfonated polyethyleneoxide [PEO-(SO3H)n]. The polymers according to the present invention are valuable as construction materials of the artificial organs for the circulatory system in contact with blood, such as artificial hearts, artificial blood vessels, artificial kidneys, etc.