Receptor polypeptides and their production and uses

摘要

An isolated TGF- beta supergene family (TSF) receptor polypeptide is provided. This polypeptide preferably is an inhibin/activin receptor polypeptide and has at least 75% sequence identity with the mature human inhibin/activin receptor sequence. Also provided is a method for purifying TGF- beta supergene family members such as inhibin or activin using the polypeptide, and a method for screening for compounds with TGF- beta supergene family member activity by contacting the compound with the polypeptide and detecting if binding has occurred and the compound is active.