摘要 |
There are disclosed compounds of the formula <IMAGE> wherein X is R1, <IMAGE> -SO2R1 or -SO2R3; R is hydrogen or lower alkyl; R1 is unsubstituted or substituted pyridyl, indolyl or quinolinyl; or substituted phenyl, thienyl, furyl, benzothienyl or benzofuryl, where the foregoing substituted moieties are substituted with halo, lower alkylcarbonyl, benzoyl, carboxy, lower alkoxycarbonyl, CON(R)2, SO2R3, cyano or trifluoromethyl; R2 is hydrogen, lower alkyl, phenyl, halo, lower alkoxy, hydroxy or trifluoromethyl; R3 is lower alkyl or phenyl; Z is -O-, -NNHR4, -NNHR1, -NOR4, -NOR1, -NOCH2R1, <IMAGE> Y is O or S; R4 is hydrogen, lower alkyl or phenyl; which by virtue of their ability to inhibit interleukin 1, are of use as antiinflammatory agents and in treatment of disease states involving enzymatic tissue destruction.
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