| 摘要 |
A compound comprising a means to direct the compound to a nucleic acid within a cell and a radioactive moiety capable of destroying adjacent biological matter. It is preferred that the means to direct the compound comprise an antisense oligonucleotide. The antisense oligonucleotide may be complementary to DNA or RNA specifically forming part of a gene for the mutant ras protein, the mutant p53 protein, the bcr ab1 protein or an HIV (human immunodeficiency virus) protein, for example the HIV gag, pol, env or sor gene products. The compound may additionally comprise a targeting portion to target the compound to a desired cell type, for example it may comprise an MAb or part thereof specific for a tumour-specific or virus-specific antigen. |
