2-PYRIDINOL DERIVATIVES AND THEIR USE AS MEDICAMENTS

摘要

2124001 9310093 PCTABS00022 Compounds of formula (1) or a pharmaceutically acceptable salt thereof, wherein: R0 is OH or a bioprecursor thereof, R1 is A0CO2H, P(Z)(OH)(OR2), SO2H or SO3H or a bioprecursor thereof, A0 is CH2, CHF, CF2, CR3(OR4), CO or C(OR5)(OR6), are described as agonists of a cyclic AMP-dependent protein kinase. They are useful as medicaments.