DNA ENCODING A GLYCINE TRANSPORTER AND USES THEREOF

摘要

This invention provides isolated nucleic acid molecules encoding a mammalian or human glycine transporter, vectors comprising the isolated nucleic acid molecules, mammalian cells comprising such vectors, nucleic acid probes, antisense oligonucleotides complementary to any sequence of a nucleic acid molecule which encodes a mammalian glycine transporter, and non-human transgenic animals which express DNA encoding a normal or a mutant mammalian glycine transporter. The invention also provides the mammalian or human glycine transporter proteins, antibodies directed to them, and pharmaceutical compounds related to the human glycine transporter. The invention further provides methods for determining ligand binding, detecting expression, drug screening, as well as treatments for alleviating abnormalities associated with mammalian or human glycine transporters.