| 摘要 |
<p>A murine/human chimeric anti-idiotype monoclonal antibody is provided which has murine complementarity determining regions fused to human constant regions. The antidoby preferentially binds gangliosides present on tumors, and when introduced into a human, elicits an anti-ganglioside response causing regression of cancer cells bearing the gangliosides. Further provided are a transfectoma producing the antibody, compositions containing the antibody, and cancer treating methods that involve administering the compositions to subjects.</p> |
