NON-DESENSITIZING ANALOGS OF GNRH AND OTHER BIOLOGICALLY ACTIVE LIGANDS

摘要

The present invention is directed to novel non-desensitizing analogs of a biologically active ligand having at least one 6-membered ring or 5-membered ring and a method for selecting non-desensitizing analogs of a biologically active ligand having at least one 6-membered ring or 5-membered ring. Additionally, the present invention is directed to a novel method for treating a patient in a non-desensitizing fashion with a non-desensitizing analog of a biologically active ligand having at least one 6-membered ring or 5-membered ring. Moreover, the present invention is directed to a novel method for making new and useful non-desensitizing analogs of GnRH and opiate peptides as well as the novel non-desensitizing compounds and compositions prepared thereby.