| 摘要 |
<p>A compound of formula (I) wherein Z is (a) or (b); and R1 is hydrogen, alkyl, or arylalkyl, provided that when R2 is present, R1 is absent; R2 is hydrogen, alkyl, or arylalkyl, provided that when R1 is present, R2 is absent; the dotted lines in the pyrazole ring represent double bonds between the 31- and 32-positions and between the 33- and 53-positions when R1 is present and double bonds between the 31- and 52-positions and between the 32- and 33-positions when R2 is present; or a pharmaceutically acceptable salt thereof which by virtue of its immunosuppresive activity is useful in treating transplantation rejection, host vs. graft disease, autoimmune diseases, and diseases of inflammation, by virtue of its antifungal activity is useful in treating fungal infections; and by virtue of its antitumor activity is useful in treating tumors. Intermediates possessing a 31,33-β-dicarbonyl moiety that are useful for the same purposes are also described.</p> |
