Azacyclic carboxylic acid derivatives and their preparation and use

摘要

Novel O-alkylated oximes of the general formula I <IMAGE> (I) wherein <IMAGE> wherein R1 and R2 are optionally substituted aromatic or heteroaromatic rings, R3 is hydrogen or lower alkyl, R4 is a nitrogen containing, substituted ring or an amino group carrying a substituted ring, and n and m independently are 0, 1 or 2, are potent inhibitors of GABA reuptake from the synaptic cleft.