摘要 |
<p>Compounds of formula (I): <CHEM> in which: R<1> is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulphonyl, haloalkanesulphonyl or sulphamoyl; R<2> is optionally substituted alkanoyl, optionally substituted alkenoyl, optionally substituted cycloalkylcarbonyl, substituted benzoyl, or 5,6-dihydro-1,4,2-dioxazin-3-yl; R<3> is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is -NH- or oxygen or sulphur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.</p> |
申请人 |
SANKYO COMPANY LIMITED;UBE INDUSTRIES LIMITED |
发明人 |
KOIKE, HIROYUKI;ASAI, FUMITOSHI;SUGIDACHI, ATSUHIRO;KIMURA, TOMIO;INOUE, TERUHIKO;NISHINO, SHIGEYOSHI;TSUZAKI YASUNORI |