摘要 |
<p>Novel substituted beta amino acid derivatives having the general formula: <CHEM> are provided, in which eg. R<2> is selected from the group consisting of hydrogen, lower alkyl radicals, lower alkenyl radicals, lower alkynyl radicals, alicyclic hydrocarbon radicals, aromatic hydrocarbon radicals, wherein said radicals are optionally substituted with hydroixy, lower alkoxy, lower alkyl, halogen, nitro, cyano, azido, ureido, ureylene, carboxyl or carbonyl derivatives, trifluoromethyl, acyloxy, alkylthio, arylthio, alkylsulfenyl, arylsulfenyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, trialkylsilyl, aminosulfonyl, dialkylamino, alkanoylamino, aroylamino, phenyl, naphtyl, lower alkynyl which are optionally substituted with one or more of the following: halogen, nitro, lower alkoxy, lower alkyl, trialkylsilyl, azide and phenyl; the invention also pertains to pharmaceutical composition comprising such derivatives.</p> |
申请人 |
MONSANTO COMPANY;G.D. SEARLE & CO. |
发明人 |
BOVY, PHILIPPE ROGER;RICO, JOSEPH GERACE;ROGERS, THOMAS EDWARD;TJOENG, FOE SIONG;ZABLOCKI, JEFFERY ALAN |