| 摘要 |
Compounds for the treatment of cardiac insufficiency, an arterial thrombo embolism, an arterial occlusive disease, psoriasis, neurodermatitis, asthma, platelet aggregation and hypertension, of the formula <IMAGE> in which R1 is hydrogen, C1-6-alkyl, C2-6-alkenyl or C3-7-cycloalkyl, R2 is hydrogen, C1-6-alkyl, C2-6-alkenyl or C1-6-hydroxyalkyl, R1 and R2 together with the carbon atom which carries them can be C3-7-spiroalkyl, R3 is hydrogen or C1-6-alkyl, and R4 is a cyanamido group, a 4-difluoromethoxy-3-pyridyl group or a C1-2-nitroalkyl group, and Z is oxygen or sulphur, or a salt, acid addition salt, tautomer or optical isomer thereof.
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