发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING THE EFFECT OF TNF AND IL-1 |
摘要 |
This invention relates to methods for modulating the effects of TNF and IL-1, both the deleterious and the therapeutical effect of these cytokines. In case of deleterious effects, the invention provides methods for modulating the deleterious effect of TNF and/or IL-1 in mammals, by administering to a mammal sub-deleterious amounts of TNF and/or IL-1. The TNF and/or IL-1 to be modulated may be endogenous, i.e. generated in the organism in severe cases in amounts deleterious to the organism, or exogenously administered to a patient in amounts which are potentially deleterious. The compositions of the invention comprise effective amounts of TNF and/or IL-1 with at least one pharmaceutically acceptable carrier. The invention also relates to methods for monitoring the modulation of the TNF effect in patients treated with TNF and/or IL-1.
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申请公布号 |
US5211945(A) |
申请公布日期 |
1993.05.18 |
申请号 |
US19870094981 |
申请日期 |
1987.09.09 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
WALLACH, DAVID;HOLTMANN, HELMUT |
分类号 |
A61K38/00;A61K31/70;A61K38/19;A61K38/20;A61K38/21;A61P31/04;A61P31/12;A61P33/10;A61P35/00;A61P43/00;C07K14/545 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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