摘要 |
Disclosed are novel tetralin derivative of the formula (I): (I) where R1 is hydrogen, C1-C4-alkyl, C1-C4-alkoxy or halogen, R2 is hydrogen, C1-C6-alkyl or C3-C6-cycloalkyl, X is -CH2-CO-, -CH2-CHOH, -CH2-C(R4)OH-, -CH2-C(OCOR4)H-, -CH2-C(R4)(OCHOR5)-, -CHOH-CHOH-, -CH=CH-, -CH(OCOR4) -CH(OCOR4)-, -CH2-CH(OR4)- (where R4 and R5 are each C1-C4-alkyl) and R3 is nitrile, C2-C10-ketal or -CH(R7)(R8)- or -CO-R9, where R7 is hydrogen or C1-C3-alkyl, R8 is hydrogen, C1-C3-alkyl or -OR10 or -NR11R12 (where R10, R11 and R12 are each hydrogen, C1-C4-alkyl, C2-C20-alkanoyl or unsubstituted or substituted benzoyl) and R9 is hydrogen, halogen, C1-C4-alkyl, azido, or -OR13 (where R13 is hydrogen or C1-C8-alkyl or is C2-C6 alkyl which is substituted by one or more hydroxyl groups or a C1 -C4 - alkoxy group, or is aryl or aralkyl) and, where relevant, its physiologically tolerated salts. These derivatives are useful in the therapy of dermatological disorders and the prophylactic and therapeutic treatment of precanceroses and tumors. |