GADOLINIUM CHELATES WITH CARBOXYMETHYL DERIVATIVES OF POLYAZAMACROCYCLES AS NMR CONTRAST AGENTS

摘要

Chelates of gadolinium with 1, 4, 7-triazacyclononane-N, N', N"-triacetate (NOTA); 1, 4, 7-triazacyclododecane-N, N', N" tetraacetate (DOTA); and 1, 5, 9-triazacyclododecane-N, N", N"triacetate (DOTRA) are useful as NMR contrast agents. General formulae of these compounds are as follows: (a) NOTA: (b) DOTA: (C) DOTRA: