摘要 |
The invention relates to a salt of a basic histamine H2-receptor antagonist of formula (I) <CHEM> and a complex of bismuth with a carboxylic acid selected from tartaric acid, citric acid and alkyl citric acids, or a solvate of such a salt, wherein R<1> represents a group of formula <CHEM> where R<3> represents methyl or the group (CH2)2CONR<4>R<5> in which R<4> and R<5> both represent ethyl groups; R<2> represents a hydrogen atom or, when R<1> is the group -C(=CHNO2)NHCH3, R<2> may also represent a methyl group; and n is 3 and X is oxygen, or n is 2 and X is CH2 or sulphur; with the provisos that (i) when R<1> represents <CHEM> then X is sulphur and n is 2; (ii) when R<1> represents -C(=CHNO2)NHCH3 and R<2> is hydrogen, then X is oxygen and n is 3 or X is CH2 and n is 2; and (iii) when R<1> represents -C(=CHNO2)NHCH3 and R<2> is methyl, then X is oxygen and n is 3 or X is sulphur and n is 2. The salts and solvates thereof are useful in the treatment of gastro-intestinal disorders, such as peptic ulcer disease, gastritis and non-ulcer dyspepsia. |