PROCESS FOR THE PREPARATION N-Û3-(3-(1-PIPERIDILMETHYL)-PHENOXY¨-PROPYLÙ-ACETOXYACETAMIDE HYDROCHLORIDE
摘要
The method is suitable for industrial purposes and exhibits high yields in the separate stages, and the prepared compound can be used in the medicine. The synthesis starts with reductive alkylation of 3-hydroxybenzaldehyde with piperidine in the presence of formic acid and in the conditions of the interphasic catalysis, the formed compound is etherated with chloropropylamine hydrochloride to phenoxypropylamine, which is consecutively amidated with chloroacetylchloride and is acetylated with acetanhydride. The prepared base is transferred into hydrochloric salt in a medium of ethylacetate and hydrogen chloride.
申请公布号
BG51401(A1)
申请公布日期
1993.05.14
申请号
BG19910094504
申请日期
1991.05.27
申请人
VLAKHOV, RADOSLAV J.;TARPANOV, VELICHKO I.;PENKOV, MIKHO D.;KRIKORJAN, DIKRAN A.
发明人
VLAKHOV, RADOSLAV J.;TARPANOV, VELICHKO I.;PENKOV, MIKHO D.;KRIKORJAN, DIKRAN A.