发明名称 New process for the preparation of 20-oxo-17 alpha ,21-dihydroxylated derivatives of pregnane and new intermediates
摘要 The invention relates to a process for the preparation of the compounds (I): <IMAGE> where R1 is especially hydrogen or alkyl, R2 is alkyl and the rings A, B, C and D optionally carry one or more double bonds, one or more hydroxyl or ketone functional groups which are optionally protected, one or more halogen atoms or one or more alkyl, alkyloxy, alkenyl or alkynyl radicals, process consisting in oxidising a corresponding compound 20-formamido-21-hydroxy-17(20)-ene, in the presence of water, and then in hydrolysing the 21-formate obtained. The invention also relates to the new intermediates thus obtained.
申请公布号 FR2683530(A1) 申请公布日期 1993.05.14
申请号 FR19910013777 申请日期 1991.11.08
申请人 ROUSSEL UCLAF 发明人 BUENDIA JEAN;VIVAT MICHEL
分类号 A61K31/57;C07J5/00;C07J7/00;C07J41/00 主分类号 A61K31/57
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