发明名称 |
STABILISED ANTIBODIES |
摘要 |
The invention relates to a stabilised immunoglobulin composition comprising at least one immunoglobulin together with a stabilising amount of a chelator of copper ions such as EDTA or citrate. Preferably the immunoglobulin is an antibody, for example a recombinant CDR-grafted antibody against the CDw52 antigen, most preferably CAMPATH-1H. The invention also relates to a process for enhancing the stability of an immunoglobulin which comprises subjecting the immunoglobulin to a purification procedure capable of removing copper ions therefrom. Preferably the immunoglobulin is rendered substantially free from detectable copper ions, for example on atomic absorption spectroscopy. |
申请公布号 |
WO9308837(A1) |
申请公布日期 |
1993.05.13 |
申请号 |
WO1992GB01970 |
申请日期 |
1992.10.27 |
申请人 |
THE WELLCOME FOUNDATION LIMITED |
发明人 |
SMITH, MARJORIE;RIVEROS-ROJAS, VALENTINA |
分类号 |
G01N33/531;A61K38/00;A61K39/395;A61K47/12;C07K1/34;C07K16/00;C07K16/28;C07K19/00;C12P21/08 |
主分类号 |
G01N33/531 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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