| 摘要 |
9-Halo prostaglandins of formula (I) and their salts and cyclodextrin clathrates are new: (where Z = a gp. of formula Z1 or Z2 = Hal = Cl or F; R1 = CH2OH, COOR2 or CONHR3; R2 = H, alkyl, cycloalkyl, aryl or heterocyclyl; R3 = acyl or R2; A = CH2CH2, trans-CH=CH or C=C; W = free or functionally modified CHOH or CMeOH with OH in the alpha or beta posn.; D = 1-10C linear, 2-10C branched or 3-10C cyclic alkylene opt. substd. by F; E = O, S, a direct bond, C=C or CR6 = CR7; or D+E = a direct bond; R6 and R7 = H, Cl or 1-4C alkyl; R4 = free or functionally modified OH; R5 = H, alkyl, haloalkyl, cycloalkyl, opt. substd. aryl or heterocyclyl).
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| 申请人 |
SCHERING AG BERLIN UND BERGKAMEN, 1000 BERLIN, DE |
发明人 |
BUCHMANN, DR., BERND, W-1000 BERLIN 21, DE;SKUBALLA, DR., WERNER, W-1000 BERLIN 28, DE;VORBRUEGGEN, PROF. DR., HELMUT, W-1000 BERLIN 27, DE;RADUECHEL, DR., BERND, W-1000 BERLIN 28, DE;LOGE, DR., OLAF, W-1000 BERLIN 27, DE;ELGER, DR., WALTER, W-1000 BERLIN 33, DE;STUERZEBECHER, DR., CLAUS-STEFFEN, W-1000 BERLIN 46, DE;THIERAUCH, DR., KARL-HEINZ, W-1000 BERLIN 37, DE |
