PROCESS AND APPARATUS FOR REMOVAL OF DNA, VIRUSES AND ENDOTOXINS

摘要

A process for the removal of DNA, endotoxins and viruses from aqueous buffer solutions, aqueous pharmaceutical solutions and aqueous biological pharmaceutical solutions comprises passing one of above solutions through a single filtration device with two sections containing coated filter membranes (34, 36) and absolute pore filters (32, 38, 62, 64, 66, 68). The filter device is capable of removing up to about 98 % of the endotoxins in addition to removing viruses with an efficiency of at least 4.6 x 10<5> and DNA to less than 10 picograms per 500 mg sample.