| 摘要 |
PURPOSE:To obtain a novel phenyl derivative having excellent action to produce or stimulate the secretion of nerve grow factors with reduced side effects. CONSTITUTION:A compound of formula I [R<1> is nitro, amino (substitutible with alkyls or cycloalkyls), protected amino; R<2> is amino, protected amino, OH or the like; R<3> is amino which can be substituted with alkyls or the like, heterocyclic ring bonding through an N atoms to the ring; m is 0 to 2; n is 0 to 6 where n is 2 to 6, when m=0] and its salts: for example, N-(1- adamantyl)-(4-acetoxy-3-nitro)cinnamic amide. The compound of formula I is obtained by reaction of a reactive derivative of a carboxylic acid of formula II (Y is an eliminating group; R<1>' is a part of R<1>; R<2>' is a part of P<2>) with a compound of formula III in the presence of a base in an inert solvent, followed by reduction of the nitro into amino group, when R<1>' is nitro, if desired, and deprotection, when the amino or hydroxy group is protected. |
