VERWENDUNG CARBOCYCLISCH UND HETEROCYCLISCH ANELLIERTER DIHYDROPYRIDINE ZUR HERSTELLUNG VON CARDIOPROTEKTIVEN MITTELN SOWIE NEUE HETEROCYCLISCH UND CARBOCYCLISCH ANELLIERTE DIHYDROPYRIDINE, VERFAHREN ZU DEREN HERSTELLUNG UND ZWISCHENSTUFEN FUER DEREN HERSTELLUNG.

摘要

The use of benzyl-substd. fused pyridine cpds. of formula (I), including their salts with physiologically acceptable acids, base and complexing agents to produce cardioprotective compsn. is new. X = OR1, NHR2 or NR3R4; R1 = H, 1-4C alkyl or alkoxyalkyl, R2=H, 3-6C alkenyl, alkynyl, cycloalkyl or cycloalkenyl; or 1-6C alkyl opt. substd. by 1 or more, Same or different substits. of gps. a, b or c; (R) halo, CN, OH, SH, 1-4C alkoxy or alkylthio, or amino (opt. substd. by 1 or 2 1-4C alkyl); (b) phenyl, opt. substd. by 1 or more halo, 1-4C alkyl, alkoxy or alkylthio, OH, SH, amino (opt. substd. by 1 or 2 1-4C alkyl), 2-3C acylamino or acyloxy, or, on adjacent C atoms, -O-(CH2)nO- (n=1 or 2); (G) 5 or 6 membered, satd. or unsatd. monocyclic hetero cycle with 1-3 N, O or S, or indole, three rings opt. substd. by 1 or m alkyl, 3-6C cycloalkyl, 5-6C cycloalkenyl, 2-4C acyl 1-4C alkylsulphonyl phenyl (opt. substd. as in (b)); R3 and R4 = 1-4C alkyl, opt. substd. by phenyl (itself opt. substd. as in (b)) or together complete a 5- or 6-membered, at least partly satd. heterocycle (opt. contg. up to 2 further N, O or S, and opt. substd. by 1-4C alkyl, OH, (CH2)pR5 (p=O or1)) R5 = phenyl, opt. substd. as in (b); ring (A) is gp. (Ia)-(Id) R8 = H or 1-4C alkyl or alkoxy; R6 and R7 = H, OH, 1-4C alkyl or alkoxy, NH2, MeSO2NH or together are -O(CH2)n)-; R9 = H or 2-phenyl-2-ethoxycarbonylacetyl. (I) may exist in the tautomeric form E or Z isomers; Some (I) are new.