| 发明名称 |
THIOESTER ENANTIOMERIC COMPOUNDS AND THEIR THERAPEUTIC USES |
| 摘要 |
The (R) or (S) isomer of acetorphan or N-/2-acetylthiomethyl)-1-oxo-3-phenylpropyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-2-benzylpropanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
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| 申请公布号 |
US5208255(A) |
申请公布日期 |
1993.05.04 |
| 申请号 |
US19880274884 |
申请日期 |
1988.11.22 |
| 申请人 |
SOCIETE CIVILE BIOPROJET |
发明人 |
DUHAMEL, PIERRE;DUHAMEL, LUCETTE;DANVY, DENIS;PLAQUEVENT, JEAN-CHRISTOPHE;GIROS, BRUNO;GROS, CLAUDE;SCHWARTZ, JEAN-CHARLES;LECOMTE, JEANNE-MARIE |
| 分类号 |
A61K31/22;A61K31/255;A61K31/265;A61K38/00;A61P1/00;A61P1/08;A61P1/16;A61P9/00;A61P9/12;A61P13/02;A61P15/00;A61P25/00;A61P25/04;A61P29/00;A61P43/00;C07B57/00;C07C327/32 |
主分类号 |
A61K31/22 |
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