VANADYL COMPLEXES OF HYDROXAMATE CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

摘要

PCT No. PCT/EP92/02306 Sec. 371 Date Jun. 7, 1993 Sec. 102(e) Date Jun. 7, 1993 PCT Filed Oct. 6, 1992 PCT Pub. No. WO93/07155 PCT Pub. Date Apr. 15, 1993.Vanadyl complexes of chelating dihydroxamate compounds suitable for oral treatment of diabetes are disclosed. The dipodal hydroxamate ion carriers effectively bind and transport vanadyl ions across lipid membranes and potentiate glucose metabolism. The complexes may be generated in vivo by administration of a vanadyl salt and the hydroxamate ion carrier.