发明名称 |
DEVICE FOR THE TRANSDERMAL ADMINISTRATION OF MELATONIN |
摘要 |
2116036 9307870 PCTABS00021 The present invention is directed to the transdermal administration of melatonin together with a suitable permeation enhancer. The invention includes a transdermal drug delivery device (10) comprising a matrix (12) adapted to be placed in melatonin- and permeation enhancer-transmitting relation with the skin site (18). The matrix (12) contains sufficient amounts of a permeation enhancer and of melatonin, in combination, to continuously administer to the skin (18) for a predetermined period of time the melatonin to provide an effective therapeutic result. The invention is also directed to a method for the transdermal administration of a therapeutically effective amount of melatonin together with a skin permeation-enhancing amount of a suitable permeation enhancer. The invention further includes methods for time- and rate-patterned transdermal delivery of melatonin to simulate the natural circadian rhythmic profile of melatonin in mammals.
|
申请公布号 |
CA2116036(A1) |
申请公布日期 |
1993.04.29 |
申请号 |
CA19922116036 |
申请日期 |
1992.10.16 |
申请人 |
ALZA CORP |
发明人 |
YATES F EUGENE;TASKOVICH LINA T;YUM SU I;CRISOLOGO NIEVES M |
分类号 |
A61K9/00;A61K9/70;A61K31/40;A61K47/14;(IPC1-7):A61K31/40 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|