A process for microencapsulating bioactive substances in biocompatible polymers according to the phase-separation principle, wherein an excess of an ethyl or isopropyl ester of a straight-chain fatty acid having 12-18 carbon atoms is used as the hardening liquid, and the pharmaceutical compositions containing the microcapsules prepared by this process. Isopropyl myristate and isopropyl palmitate are preferred hardening liquids.
申请公布号
DE69001132(D1)
申请公布日期
1993.04.29
申请号
DE1990601132
申请日期
1990.01.02
申请人
BROCADES-PHARMA B.V., LEIDERDORP, NL
发明人
KOMEN, JOSEPH, NL-2024 EB HAARLEM, NL;GROENENDAAL, JAN WILLEM, NL-2611 EE DELFT, NL