| 摘要 |
Diphenyl-methane derivs. of formula (I) are new, (where R1 and R2 each = H, OH or lower alkoxy; U = -CXY or =N-O-W; X = H, CN or -COR6; R6 = OH or NH2; Y = -R10-COOR3, -CONR4R5, -CH2NHSO2-C6H5 or -C(R8)=NR7; R3 = H or lower alkoxy; R10 = opt. branched 1-3C alkylene; R4 and R5 each = H, lower alkyl or lower arylalkyl; R7 = lower alkoxy or aryl; R8 = -VR9; V = O, S or N; R9 = alkyl or aryl; W = -CH2-CO-CH2-COOR13, -CH2-C(=NOR14)-CH2-COOR15, -CH(CN)-(CH2)q-COOR16 or -(CH2)p-Z; R13 = H or lower alkyl; R14 = lower alkyl; R15 = H or lower alkyl; R16 = H or lower alkyl; q = 1-3; Z = -SH, -SCN or a monovalent gp. derived from a 5- or 6-membered ring opt. substd. by a ring with 1 or more S in the ring; p = 1 or 2. |
| 申请人 |
EISAI CO., LTD., TOKIO/TOKYO, JP |
发明人 |
YAMATSU, ISAO, USHIKU-SHI IBARAKI, JP;HARADA, KOUKICHI, YATABEMACHI TSUKUBA-GUN IBARAKI, JP;FUJIMORI, TOHRU, TSUKUBA-GUN IBARAKI, JP;YOSHIMURA, HIROYUKI, YATABEMACHI TSUKUBA-GUN IBARAKI, JP;HAYASHI, KENJI, TSUKUBA-GUN IBARAKI, JP;IKUTA, HIRONORI;ABE, SHINYA, USHIKU-SHI IBARAKI, JP;OKANO, KAZUO, YATABEMACHI TSUKUBA-GUN IBARAKI, JP;NAKAMOTO, KOUJI, TSUCHIURA-SHI IBARAKI, JP;MIYAMOTO, MITSUAKI, NIIHARI-GUN IBARAKI, JP;SUZUKI, TAKESHI;AKASAKA, KOZO, USHIKU-SHI IBARAKI, JP;YAMAGISHI, YOUJI, NIIHARI-GUN IBARAKI, JP |
