| 摘要 |
2118920 9308166 PCTABS00021 The present invention encompasses: 1) compounds of formula (I), wherein p and s are independent and may be either 1 or 2, wherein R1 is -H, -Halo, -CN, -CO2H, -CO2R1-1, -CONH2, -CONHR1-1, -CON(R1-1)2, -SH, -SR1-1, -SO2R1-1, -SO2NH2, -SO2NHR1-1, -SO2N(R1-1)2, -OR1-1, -OSO2CF3, -OSO2R1-1, -NH2, -NHR1-1, or -N(R1-1)2; wherein R1-1 is -H, -(C1-C8 alkyl), -(C1-C8 alkenyl), -(C3-C10 cycloalkyl), -(C6 aryl), -5 or 6 member heterocyclics, -(C1-C8 alkyl)-(5 or 6 member heterocyclics), wherein R2 is -H, -Halo, -CN, -CF3, -SH, or -SR2-1; wherein R2-1=R1-1, wherein R3 is -H, -(C1-C8 alkyl), -(C1-C8 alkenyl), -(C6 aryl), -(C3-C10 cycloalkyl), -(5 or 6 member heterocyclics), -(C1-C8 alkyl)-5 or 6 member heterocyclics), wherein R3-1=R1-1 or a pharmacologically acceptable salt thereof; 2) a pharmaceutical composition consisting essentially of a pharmaceutically acceptable carrier and an effective amount of a compound of formula (I); 3) a method of treating central nervous system disorders, associated with serotonin and/or dopamine receptor activity comprising: administering an effective amount of a compound of formula (I) to a patient in need thereof. The compounds of this invention possess selective pharmacological properties and are useful in treating central nervous system disorders.
|
