NOVEL CYCLIC AMINOPHENYLACETIC ACID DERIVATIVE, PRODUCTION THEREOF, AND IMMUNE RESPONSE MODULATOR CONTAINING THE SAME AS ACTIVE INGREDIENT.

摘要

A novel cyclic aminophenylacetic acid derivative which has an immune response modulatory activity, represented by general formula (1), an optical isomer thereof and salts thereof, a process for producing the same, and a remedy for autoimmune diseases containing the same as an active ingredient. In Formula (1), R and R<1> represent each independently hydrogen or C<5> to C<7> lower alkyl; R<2> represents trifluoromethyl or phenyl which may be substituted by one to three groups selected among halogen, methoxy and combinations thereof; and X represents hydrogen, C<5> to C<7> lower alkyl, C<5> to C<7> lower alkoxy, cyano, thiocyano, trimethylsilylethynyl, phenyl which may be substituted by one to three groups selected among halogen, methoxy, methyl and combinations thereof, carbamoyl, carboxyl, C<5> to C<7> lower alkoxycarbonyl, acetyl, benzoyl, nitro, amino, C<5> to C<7> lower alkanoylamino, benzoylamino which may be substituted, phenylsulfonylamino which may be substituted, C<5> to C<7> lower alkylthio, C<5> to C<7> lower alkylsulfinyl, C<5> to C<7> lower alkylsulfonyl or halogen.