| 发明名称 |
Cytotoxic bicyclo (7.3.1)-tridec-4-ene-2,6-diyne compounds and process for the preparation thereof. |
| 摘要 |
<p>The present invention relates to a novel and efficient process for the preparation of 8-hydroxy-bicycloÄ7.3.1Ütridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic antitumor agents having said bicyclic ring system. The present invention also provides a method for treating mammalian malignant tumors by administering to an animal in need of such treatment an antitumor effective amount of a compound of the present invention.</p> |
| 申请公布号 |
EP0538898(A2) |
申请公布日期 |
1993.04.28 |
| 申请号 |
EP19920118220 |
申请日期 |
1992.10.23 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
KADOW, JOHN F.;WITTMAN, MARK D. |
| 分类号 |
A61K31/12;A61K31/215;A61K31/265;A61K31/27;A61K31/44;A61K31/4402;A61P35/00;C07C45/64;C07C45/67;C07C45/84;C07C49/733;C07C67/08;C07C67/14;C07C68/02;C07C69/013;C07C69/08;C07C69/16;C07C69/96;C07C269/04;C07C271/34;C07C323/22;C07D213/75;C07D241/44;C07D303/32;C07D309/12;C07F7/18;C07F15/06 |
主分类号 |
A61K31/12 |
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