Chemical prevention or reversal of cataract by phase separation inhibitors.

摘要

A reagent comprising: a compound having two actions, the first action decreasing phase separation temperature of lens cytoplasmic proteins below the patient's body temperature and the second action inhibiting the formation of high molecular weight aggregates, wherein said compound is able to diffuse into the lens and is non-toxic to the lens and surrounding tissue, having no substantial effect on eye color and viscoelastic properties of the lens affecting visual acuity, and wherein preferred compounds are selected from the group consisting of succinimide, N-hydroxy succinimide, ethosuximide and pantethenic acid derivatives may be used in the in vivo prevention or reversal of phase separation cataract formation in a human or animal patient.