发明名称 |
PROCESS FOR STEREOSELECTIVE PRODUCTION OF PHENYLISOSERINE DERIVATIVES |
摘要 |
<p>PCT No. PCT/FR91/00406 Sec. 371 Date Nov. 20, 1992 Sec. 102(e) Date Nov. 20, 1992 PCT Filed May 21, 1991 PCT Pub. No. WO91/17977 PCT Pub. Date Nov. 28, 1991.A stereoselective process for preparing phenylisoserine derivatives is disclosed. Benzylamine is reacted with an agent for introducing a phenyl or a t-butoxycarbonyl group. The product undergoes double anionization and then is reacted with acrolein to provide a mixture of alcohol syn and anti diasteroisomers. The syn isomer is isolated by chromatography. Whereupon, the hydroxyl is protected and the product is oxidized to provide the phenylisoserine derivative.</p> |
申请公布号 |
HUT62260(A) |
申请公布日期 |
1993.04.28 |
申请号 |
HU19920003651 |
申请日期 |
1991.05.21 |
申请人 |
RHONE-POULENC RORER S.A.,FR |
发明人 |
DENIS,JEAN-NOEL,FR;CORREA,ARLENE GONCALVES,FR;GREENE,ANDREW ELLIOT,FR |
分类号 |
C07C235/84;A61K31/16;C07B57/00;C07C229/34;C07C231/12;C07C231/18;C07C233/31;C07C233/47;C07C233/83;C07C269/06;C07D305/14;(IPC1-7):C07C229/34;C07B53/00 |
主分类号 |
C07C235/84 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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