| 摘要 |
A method of overcoming the resistance of a progressively growing tumor in a host to lymphocytotoxic effector cells conferred by an anti-tumor polyclonal antibody response induced in the host. Themethod comprises the steps of obtaining a sample of the progressively growing tumor from the host, generating at least one human monoclonal antibody directed against at least one oncotope of the progressively growing tumor, subjecting the human monoclonal antibody to an analysis to make a determination of the therapeutic value of the human monoclonal antibody, generating a blocking human antibody which blocks anti-oncotope monoclonal antibodies; and delivering a therapeutic amount of the blocking human antibody to the host to permit the tumor to expose uncovered oncotopes thereby becoming sensitive to lymphocytotoxic effector cells. |
