A chimeric gene directing the synthesis of hybrid recombinant fusion protein in a suitable expression vector has been constructed. The fusion protein possesses the property of selective cytotoxicity against specific virus-infected cells. A CD4(178)-PE40 hybrid fusion protein has been made for selectively killing HIV-infected cells.
申请公布号
US5206353(A)
申请公布日期
1993.04.27
申请号
US19880223270
申请日期
1988.07.23
申请人
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
BERGER, EDWARD A.;MOSS, BERNARD;FUERST, THOMAS R.;PASTAN, IRA;FITZGERALD, DAVID;MIZUKAMI, TAMIO;CHAUDHARY, VIJAY K.
