Two immortalized human mammary epithelial cell sublines are provided. The sublines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The sublines exhibit positive reactivity with milk-fat globule membrane and cytokeratin anti-sera and are non-tumorigenic in athymic mice. The sublines are useful in evaluating the capacity of preselected agents to bring about a change in epithelial cell growth and in the production of proteins.
申请公布号
US5206165(A)
申请公布日期
1993.04.27
申请号
US19910727518
申请日期
1991.07.09
申请人
MICHIGAN CANCER FOUNDATION
发明人
PAULEY, ROBERT J.;PAINE, TERRY J.;SOULE, HERBERT D.