HYDROXAMSAEUREN.

摘要

Peptide-contg. hydroxamic acids of formula (I) and their salts and maleate esters are new. R1 = 2-7C alkyl; R2, R3 = amino acid residues; n = 1 or 2; A = H or CHR4CONH2; R4 = amino acid residue. (I) in which R1 = iBu or n-pentyl; R2, R3 = amino acid residues derived from glycine, alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, tryptophan, serine, threonine, cysteine, methionine asparagine, glutamine, lysine, arginine, glutamic acid or aspartic acid, provided that the residues do not have an acidic terminus but may have an acidic side chain; R4 = gp. of particular values defined for R2, R3; n = 1. 4 Cpds. (I) are specifically claimed, including (R,S)-N-(2-(2-hydroxyamino) -2-oxoethyl)-1-oxoheptyl)-L-leucyl-L -phenylalaninamide (Ia).